ICG-001
- Product Name
- ICG-001
- CAS No.
- 847591-62-2
- Chemical Name
- ICG-001
- Synonyms
- ICG-1;ICG-001;CS-1928;ICG001 isomer;ICG-001/ICG001;ICG 001, >=98%;ICG-001 isomer;PRI-724 isomer;ICG 001 isomer.;ICG-001;ICG 001;ICG001
- CBNumber
- CB62520386
- Molecular Formula
- C33H32N4O4
- Formula Weight
- 548.63158
- MOL File
- 847591-62-2.mol
ICG-001 Property
- Density
- 1.37
- storage temp.
- +2C to +8C
- solubility
- Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 25 mg/ml).
- form
- Off-white powder
- color
- Off-white
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
N-Bromosuccinimide Price
- Product number
- 5.04712
- Product name
- β-Catenin/Tcf Inhibitor VI, ICG-001 - CAS 847591-62-2 - Calbiochem
- Packaging
- 10MG
- Price
- $280
- Updated
- 2024/03/01
- Product number
- 16257
- Product name
- ICG-001
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $28
- Updated
- 2021/12/16
- Product number
- 16257
- Product name
- ICG-001
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $63
- Updated
- 2021/12/16
- Product number
- 16257
- Product name
- ICG-001
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $112
- Updated
- 2021/12/16
- Product number
- 16257
- Product name
- ICG-001
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $245
- Updated
- 2021/12/16
ICG-001 Chemical Properties,Usage,Production
Description
ICG-001 (847591-62-2) inhibits TCF/β-catenin mediated transcription by specifically blocking β-catenin/CBP interaction
Uses
(S,S)-ICG 001 is a β-turn peptidomimetic molecule inhibitor of β-catenin-Tcf-mediated transcription.
Definition
ChEBI: (6S,9aS)-6-[(4-hydroxyphenyl)methyl]-8-(1-naphthalenylmethyl)-4,7-dioxo-N-(phenylmethyl)-3,6,9,9a-tetrahydro-2H-pyrazino[1,2-a]pyrimidine-1-carboxamide is a peptide.
General Description
A cell-permeable pyrazinopyrimidinecarboxamide that competes against β-catenin for CBP (CREB-binding protein) binding and selectively prevents CBP- but not p300-, dependent TCF/β-catenin transcriptional regulations both in cultures in vitro (5 to 25 μM) and in mice in vivo (5 mg/kg/day via osmotic pump infusion), while not affecting CBP-dependent transcriptional activities mediated by the AP-1 or CRE complex. Shown to reactivate p300//TCF/β-catenin-mediated neuronal differentiation upon NGF stimulation in PS-1 L286V mutant-expressing PC-12 cultures and be efficacious in alleviating bleomycin- (0,08 units/50 μL/mouse; administered intranasally; Cat. No. 203401) induced pulmonary fibrosis in mice.
Biochem/physiol Actions
Cell permeable: yes
References
1) Emami?et al.?(2004),?A small molecule inhibitor of β-catenin/CREB-binding protein transcription;? Proc. Natl. Acad. Sci. USA,?101?12682 2) Zhou?et al.?(2012), Interactions?between β-catenin and transforming growth factor-β signaling pathways mediate epithelial-mesenchymal transition and are dependent on the transcription co-activator cAMP-response element-binding protein (CERB)-binding protein (CBP);??J. Biol. Chem.,?287?7026
ICG-001 Preparation Products And Raw materials
Raw materials
Preparation Products
ICG-001 Suppliers
- Tel
- 44-20819178-90 02081917890
- Fax
- (0)2080432064
- info@novachemistry.com
- Country
- United Kingdom
- ProdList
- 4381
- Advantage
- 58
View Lastest Price from ICG-001 manufacturers
- Product
- ICG-001 847591-62-2
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 20kg
- Release date
- 2019-12-23